Every protein in our body has a specific role and shape. Proteostasis, the balance of synthesizing, folding, and degrading proteins, is crucial. It’s vital for cells to function properly, impacting health and longevity. As we age, our cells’ ability to maintenance of proteostasis diminishes; this can lead to the accumulation of misfolded proteins and pave the way for age-related diseases.
The ubiquitin-proteasome system (UPS) is a mechanism responsible for degrading misfolded proteins. It’s particularly important for skeletal muscles, mitochondria, and neuromuscular junctions. Age-related muscle loss is linked to changes in the UPS system, emphasizing the significance of protein balance for muscle health and longevity (1).
Additionally, studies have shown that maintaining energy metabolism allows older animals to survive. High ATP (Adenosine Triphosphate) levels in older animals enable the balance of energy and protein, crucial for vital processes (2). ATP is the energy source for our cells and is essential for carrying out life processes. In short, energy metabolism and protein balance complement each other for a long life.
At Longevicals, we are deeply committed to the science of longevity. Our focus is on progress guided by the latest scientific insights. By supporting your proteostasis and energy metabolism, we aim to deliver premium products to help you achieve a long and healthy life.
Understanding and supporting proteostasis helps us combat the negative effects of cellular aging, providing vitality and longevity.
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References:
- Hughes, D. C., Baehr, L. M., Waddell, D., Sharples, A., & Bodine, S. (2022). Ubiquitin Ligases in Longevity and Aging Skeletal Muscle. International Journal of Molecular Sciences.
- Chaudhari, S. N., & Kipreos, E. (2018). The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity. BioEssays.